Expert Interview
Discussing prime editing, how it compares to CRISPR/Cas9, and it's potential in future therapeutics.
Ticker(s): PRME, VRTX, CRSPAssociate Professor in the Department of Integrative Biology at University of Colorado. The main interests in our lab revolve around understanding the functions of the enzyme glycogen synthase kinase-3 (Gsk-3) isoforms. We are utilizing a systems biology approach to understanding Gsk-3 function in maintaining pluripotency of embryonic stem cells. We have recently identified a role for Gsk-3 in regulating the methylation of mRNA. This modification, referred to as m6A, affects many aspects of RNA biology, including regulating the stability of mRNA and the translational efficiency. We are currently investigating the mechanisms underlying these effects, and their implications on the biology of stem cells.
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